Phenylpropanoids and polyketides
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 1 G
Dibenzoylmethane is a minor ingredient found in licorice that functions as a Keap1-Nrf2 activator. It is known to prevent various cancers and oxidative damage. As an analog of curcumin, it facilitates dissociation from Keap1, leading to the nuclear translocation of Nrf2.
- Activates Nrf2
- Prevents various cancers and oxidative damage
- Increases mRNA level of HO-1 in HepG2 cells
- Induces HO-1 and Nrf2 protein expression
- Increases phosphorylated protein levels of Erk1/2, p38MAPK, JNK, AMPK, and Akt in HepG2 cells
- Reduces area and severity of necrosis and leukocyte infiltration
- Protects against CCl4-induced liver damage
Medchemexpress LLC (S)-(+)-1,2-Propanediol | 4254-15-3 | MFCD00004539 | 100.0% | C3H8O2 | 500 G
(S)-(+)-1,2-Propanediol is an endogenous metabolite that serves multiple functions. It can be used as an organic solvent and diluent in drug preparations, a chiral synthetic intermediate, and a substrate for enzyme research.
- Endogenous metabolite
- Functions as an organic solvent
- Used as a diluent in drug preparations
- Acts as a chiral synthetic intermediate
- Can be a substrate for enzyme research
eMolecules Amino(4-tert-butylphenyl)acetic acid | 299165-27-8 | MFCD02662470 | 1g
Combi-Blocks | Amino(4-tert-butylphenyl)acetic acid | 1g | 517033821 | QA-1517 | 96.000 | 299165-27-8 | MFCD02662470 | 207.273 | C12H17NO2
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Aobious Inc iST2-1, 200MG
ABIOUS | iST2-1, 2-(4-Methoxyphenyl)-1-((5-(2-nitrophenyl)furan-2-yl)methyl)pyrrolidine | 200MG g | AOB36416-200MG | Purity: 98% by HPLC | 1019158-02-1 | MW: 378.43
Medchemexpress LLC Avobenzone | 70356-09-1 | 98.0% | 10 G
Avobenzone is a dibenzoylmethane compound widely used as a filter in sunscreens for skin photoprotection in the UVA band. It is also identified as an endocrine disruptor that directly binds to estrogen receptor β and acts as an estrogen agonist.
- Widely used as a filter in sunscreens for UVA band skin photoprotection
- Acts as an endocrine disruptor and estrogen agonist
- Promotes adipogenesis in hBM-MSCs
- Up-regulates mRNA levels of PPARγ during adipogenesis
- Inhibits proliferative activities of human trophoblast cells
- Induces apoptosis in HTR8/SVneo cells
- Exhibits weak ERα agonism and weak AR antagonism
Medchemexpress LLC Dibenzoylmethane | 120-46-7 | 98.0% | 224.26 | 50 G
Dibenzoylmethane is a minor ingredient in licorice that activates Nrf2 and prevents various cancers and oxidative damage. It is an analog of curcumin and results in dissociation from Keap1 and nuclear translocation of Nrf2.
- Purity is 98.0%.
- Appearance is solid.
- Color is off-white to light yellow.
- Initial source is Plants Leguminosae Glycyrrhiza uralensis Fisch.
Medchemexpress LLC Xanthohumol | 6754-58-1 | 354.40 | 1 G
Xanthohumol is a principal flavonoid isolated from hops. It acts as an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2, demonstrating anti-cancer and anti-angiogenic activities. It also exhibits antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Inhibitor of DGAT, COX-1, and COX-2.
- Exhibits anti-cancer and anti-angiogenic activities.
- Possesses antiviral activity against several viruses.
Medchemexpress LLC Xanthohumol | 6754-58-1 | 354.40 | 50 MG
Xanthohumol is a prominent flavonoid isolated from hops. It acts as an inhibitor of diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2. It exhibits anti-cancer and anti-angiogenic activities. Additionally, Xanthohumol possesses antiviral activity against bovine viral diarrhea virus (BVDV), rhinovirus, HSV-1, HSV-2, and cytomegalovirus (CMV).
- Inhibits diacylglycerol acetyltransferase (DGAT), COX-1, and COX-2.
- Possesses anti-cancer activities.
- Exhibits anti-angiogenic activities.
- Shows antiviral activity against BVDV, rhinovirus, HSV-1, HSV-2, and CMV.
Selleck Chemical LLC Xanthohumol
Xanthohumol a prenylated chalcone from hop inhibits COX-1 and COX-2 activity and shows chemopreventive effects Xanthohumol inhibits diacylglycerol acyltransferase 1 (DGAT1) and DGAT2 with both IC50 of 40 M Xanthohumol is also a potent antiviral agent against a series of DNA and RNA viruses Xanthohumol induces growth inhibition and apoptosis in cancer cells Phase 1